LCModel
Application:
- Automatic quantification of in vivo proton MR spectra.
- Some user applications of LCModel can be seen in the sample publications list.
Recent News:
LCModel Version 6.2 (free upgrade for current LCModel sites). While the main application remains brain, options have been added for more primitive spectra:- Mainly water & lipids, as in bone marrow.
- Water & lipids plus possibly choline, as in
breast and
liver.
- LCModel Version 6.1 (free upgrade for current LCModel sites) with new
options, including analysis of muscle spectra,
particularly for IMCL.
- A Linux version for PCs (with Intel or AMD processors) is
now available. It is much faster than UNIX, with an excellent hardware
performance/price ratio, particularly interesting for MRSI.
- In Japan, you obtain LCModel (and support) directly
from the exclusive LCModel distributor for Japan, L.A. Systems,
http://www.las.jp.
- Major new LCModel Version 6 (free upgrade for current LCModel sites)
with many new features, including:
- Estimates of macromolecule and lipid contributions in normals and in pathologies (e.g., tumors) with strong lipid signals and without strong lipid signals.
- Analyses of full 2D slices or rectangular 2D subsets of 2D or 3D MRSI
data sets.
Features:
- Fully automatic, non-interactive, operator-independent: time-domain
data input, one-page summary output.
- Fully developed, over 20 years, with spectra analyzed from a wide variety of scanners and field strengths at more than 600 sites.
Download, Install & Test:
- You can freely download the complete LCMgui/LCModel package for your Linux PC. (The two
commands needed for
installation and the run with the test data are also specified.) You can also
test the preparation and input of your own data to LCModel.
- You can fully enable your LCModel package to analyze all data (not just the test data) with a license.
Methods are described in:
- S.W. Provencher: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30, 672 (1993).
- User's Manual (you can always get the latest version here).
LCMgui Graphical User Interface
The normal usage is to supply the time-domain data as a simple text file to LCModel. A possible alternative is the LCMgui graphical user interface:- Freely available for use with LCModel.
- Simplified usage, often only with mouse clicks, in two steps:
- Select the data with the File Selector;
- Start LCModel (optionally checking and modifying any settings) in the Control Window.
- Select the data with the File Selector;
- Currently for the following single-voxel data:
- Bruker ParaVision
fidfiles (if necessary, converted by you to analog mode with Bruker'sconvdta).
- GE 5.x Probe raw P-files and spectrum G-files.
- GE Probe raw P-files, including
(new)
Signa 22 P-files.
Also for P-files with multi-channel (phased-array) data.
- Hitachi data: part of the Hitachi software; no need to purchase
separately.
- Philips SDAT & SPAR files.
- Picker (later Marconi, now Philips) DUMP files.
- Siemens *rda files transferred from the syngo PC
console and
Siemens raw files from the (old) Numaris-3 Unix console.
- Toshiba rawData files and
Version 7.xx (and later) DICOM files;
- Varian/Agilent fid files;
- Other data types using your own conversion script.
- Bruker ParaVision
- Currently for the following MRSI data:
- Philips, Siemens & Toshiba data,
including interactive display, selection and analysis of full 2D slices or
rectangular subsets. (Instructions in Sec. 3.7 of the LCModel Manual.)
- Other data types using your own conversion script;
- For GE MRSI (and single-voxel) data, Mary
McLean's LCModel interface [MA McLean et al, Magn Reson Med
44, 401 (2000)] is integrated into GE's SAGE
Research version (from SAGE Dev2002.1).
- Philips, Siemens & Toshiba data,
including interactive display, selection and analysis of full 2D slices or
rectangular subsets. (Instructions in Sec. 3.7 of the LCModel Manual.)
Contact LCMODEL Inc.: sp@lcmodel.CA
To Inverse Problems home page
Last modified: 01 January 2012